How dsRNA
are loaded into Argonaut, the major player of human and plant RNAi? This key
step is key to the discussion on how improbable would the load of
external, gut-derived dsRNA into Argonaut be.
Therefore,
for the sake of a fruitful discussion on this subject at Brazilian CTNBio and other
distinguished risk assessment commissions, I strongly suggest the careful reading of the paper
below.
Small RNA
sorting: matchmaking for Argonautes
Benjamin
Czech & Gregory J. Hannon
Nat. Rev.
Genet. 12(1): 19-31 (2011)
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